Testing a quintessence model with CMBR peaks location

We show that a model of quintessence with exponential potential, which allows to obtain general exact solutions, can generate locations of CMBR peaks which are fully compatible with present observational dataComment: 7 pages, no figure

Stress responses in down syndrome neurodegeneration: State of the art and therapeutic molecules

Down syndrome (DS) is the most common genomic disorder characterized by the increased incidence of developing early Alzheimer’s disease (AD). In DS, the triplication of genes on chromosome 21 is intimately associated with the increase of AD pathological hallmarks and with the development of brain redox imbalance and aberrant proteostasis. Increasing evidence has re-cently shown that oxidative stress (OS), associated with mitochondrial dysfunction and with the failure of antioxidant responses (e.g., SOD1 and Nrf2), is an early signature of DS, promoting protein oxidation and the formation of toxic protein aggregates. In turn, systems involved in the surveil-lance of protein synthesis/folding/degradation mechanisms, such as the integrated stress response (ISR), the unfolded stress response (UPR), and autophagy, are impaired in DS, thus exacerbating brain damage. A number of pre-clinical and clinical studies have been applied to the context of DS with the aim of rescuing redox balance and proteostasis by boosting the antioxidant response and/or inducing the mechanisms of protein re-folding and clearance, and at final of reducing cognitive decline. So far, such therapeutic approaches demonstrated their efficacy in reverting several aspects of DS phenotype in murine models, however, additional studies aimed to translate these approaches in clinical practice are still needed

Are collapse models testable with quantum oscillating systems? The case of neutrinos, kaons, chiral molecules

Collapse models provide a theoretical framework for understanding how classical world emerges from quantum mechanics. Their dynamics preserves (practically) quantum linearity for microscopic systems, while it becomes strongly nonlinear when moving towards macroscopic scale. The conventional approach to test collapse models is to create spatial superpositions of mesoscopic systems and then examine the loss of interference, while environmental noises are engineered carefully. Here we investigate a different approach: We study systems that naturally oscillate --creating quantum superpositions-- and thus represent a natural case-study for testing quantum linearity: neutrinos, neutral mesons, and chiral molecules. We will show how spontaneous collapses affect their oscillatory behavior, and will compare them with environmental decoherence effects. We will show that, contrary to what previously predicted, collapse models cannot be tested with neutrinos. The effect is stronger for neutral mesons, but still beyond experimental reach. Instead, chiral molecules can offer promising candidates for testing collapse models.Comment: accepted by NATURE Scientific Reports, 12 pages, 1 figures, 2 table

Endoscopic scores for inflammatory bowel disease in the era of 'mucosal healing'. old problem, new perspectives

The importance of the endoscopic evaluation in inflammatory bowel disease (IBD) management has been recognized for many years. However, the modalities for reporting endoscopic activity represent an ongoing challenge. To address this, several endoscopic scores have been proposed. Very few have been properly validated, and the use of such tools remains sub-optimal and is mainly restricted to clinical trials. In recent years, a growing emphasis of the concept of 'mucosal healing' as a prognostic marker and therapeutic goal has increased the need for a more accurate definition of endoscopic activity in both ulcerative colitis (UC) and Crohn's Disease (CD). In the present review, the evolution of the challenges related to endoscopic scores in IBD has been analyzed, with particular attention paid to the renewed relevance of endoscopic activity in recent years. Currently, despite the growing relevance of endoscopic activity, evaluating this activity in IBD is still a challenge. The implementation of efficacious endoscopic scores and a better definition of the absence of activity (mucosal healing) are needed.The importance of the endoscopic evaluation in inflammatory bowel disease (IBD) management has been recognized for many years. However, the modalities for reporting endoscopic activity represent an ongoing challenge. To address this, several endoscopic scores have been proposed. Very few have been properly validated, and the use of such tools remains sub-optimal and is mainly restricted to clinical trials. In recent years, a growing emphasis of the concept of 'mucosal healing' as a prognostic marker and therapeutic goal has increased the need for a more accurate definition of endoscopic activity in both ulcerative colitis (UC) and Crohn's Disease (CD). In the present review, the evolution of the challenges related to endoscopic scores in IBD has been analyzed, with particular attention paid to the renewed relevance of endoscopic activity in recent years. Currently, despite the growing relevance of endoscopic activity, evaluating this activity in IBD is still a challenge. The implementation of efficacious endoscopic scores and a better definition of the absence of activity (mucosal healing) are needed

Noise, age and gender effects on speech intelligibility and sentence comprehension for 11- to 13-year-old children in real classrooms.

The present study aimed to investigate the effects of type of noise, age, and gender on children\u2019s speech intelligibility (SI) and sentence comprehension (SC). The experiment was conducted with 171 children between 11 and 13 years old in ecologically-valid conditions (collective presentation in real, reverberating classrooms). Two standardized tests were used to assess SI and SC. The two tasks were presented in three listening conditions: quiet; traffic noise; and classroom noise (non-intelligible noise with the same spectrum and temporal envelope of speech, plus typical classroom sound events). Both task performance accuracy and listening effort were considered in the analyses, the latter tracked by recording the response time (RT) using a single-task paradigm. Classroom noise was found to have the worst effect on both tasks (worsening task performance accuracy and slowing RTs), due to its spectro-temporal characteristics. A developmental effect was seen in the range of ages (11\u201313 years), which depended on the task and listening condition. Gender effects were also seen in both tasks, girls being more accurate and quicker to respond in most listening conditions. A significant interaction emerged between type of noise, age and task, indicating that classroom noise had a greater impact on RTs for SI than for SC. Overall, these results indicate that, for 11- to 13-year-old children, performance in SI and SC tasks is influenced by aspects relating to both the sound environment and the listener (age, gender). The presence of significant interactions between these factors and the type of task suggests that the acoustic conditions that guarantee optimal SI might not be equally adequate for SC. Our findings have implications for the development of standard requirements for the acoustic design of classrooms

Are Collapse Models Testable via Flavor Oscillations?

Collapse models predict the spontaneous collapse of the wave function, in order to avoid the emergence of macroscopic superpositions. In their mass-dependent formulation they claim that the collapse of any system's wave function depends on its mass. Neutral K, D, B mesons are oscillating systems that are given by Nature as superposition of different mass eigenstates. Thus they are unique and interesting systems to look at, for analyzing the experimental implications of such models, so far in agreement with all known experiments. In this paper we derive - for the single mesons and bipartite entangled mesons - the effect of the mass-proportional CSL collapse model on the dynamics on neutral mesons, including the relativistic effects. We compare the theoretical prediction with experimental data from different accelerator facilities.Comment: 20 pages, RevTe

Quantum marking and quantum erasure for neutral kaons

Entangled K0 anti-K0 pairs are shown to be suitable to discuss extensions and tests of Bohr's complementarity principle through the quantum marking and quantum erasure techniques suggested by M. O. Scully and K. Druehl [Phys. Rev. A 25, 2208 (1982)]. Strangeness oscillations play the role of the traditional interference pattern linked to wave-like behaviour, whereas the distinct propagation in free space of the K_S and K_L components mimics the two possible interferometric paths taken by particle-like objects.Comment: 4 RevTeX page

Occurrence of Coxiella burnetii in goat and ewe unpasteurized cheeses: Screening and genotyping

Q fever is a zoonosis caused by Coxiella burnetii which infects humans as well as several animal species; sheep, goats and cattle are the primary animal reservoir. The main route of human exposure to Coxiella burnetii is inhalation of contaminated aerosols from excreta, especially birth products, while the role of unpasteurized dairy products in the transmission of Q fever to humans remains still controversial. The aim of this work was to evaluate the presence of Coxiella burnetii in unpasteurized cheese samples (n=84) by PCR and to genotype the circulating strains by Multispacer sequence typing (MST) analysis. Coxiella burnetii DNA was detected in 27/84 (32.14%) cheeses and positivity rate of handicraft cheeses reached 17.24%, while positivity rate of non-handicraft cheeses reached 65.38%. In addition, the MST profile of Coxiella burnetii detected in 5 cheese samples have shown the circulation of ST12 and ST32 genotypes in Tuscany

Fluid structure interaction analysis: vortex shedding induced vibrations

Abstract Fluid Structure Interaction (FSI) numerical modelling requires an efficient workflow to properly capture the physics involved. Computational Structural Mechanics (CSM) and Computation Fluid Dynamics (CFD) have to be coupled and at the moment there is a lack of monolithic solvers capable to tackle industrial applications that involves high fidelity models which mesh can be comprised of hundred millions of cells. This paper shows an efficient approach based on standard commercial tools. The FEM solver ANSYS® Mechanical™ is used to extract a given number of eigenmodes. Then the modal shapes are imported in the CFD solver Fluent® using the Add On RBF Morph™. Updating the modal coordinates it is possible to adapt the shape of the model by taking into account the elasticity of the CFD model. Transient analysis is faced using a time marching solution by updating the shape of the mesh at each time step (weak coupling, evaluated as single DOF systems and integrating modal forces over the CFD grid). Numerical performances and solution accuracy of this approach are analyzed on a practical application (NACA0009 Hydrofoil) for which experimental data are available. A comparison between proposed method and experiment is provided. Transient coupled solver is used for the computation of eigenvalues in water by post processing the free vibration response in calm fluid